{"id":108,"date":"2023-10-17T11:19:07","date_gmt":"2023-10-17T11:19:07","guid":{"rendered":"https:\/\/www.aumedimmunology.cz\/?page_id=108"},"modified":"2025-09-23T08:19:57","modified_gmt":"2025-09-23T08:19:57","slug":"transfer-faktor-tfi","status":"publish","type":"page","link":"https:\/\/www.aumedimmunology.cz\/?page_id=108","title":{"rendered":"Transfer faktor TFI"},"content":{"rendered":"\n

TFI je nov\u00e1 l\u00e9kov\u00e1 forma specifick\u00fdch imunomodul\u00e1tor\u016f na b\u00e1zi transfer faktor\u016f (TF) pod\u00e1van\u00e1 peror\u00e1ln\u011b ve form\u011b lyofilizovan\u00e9 tablety. <\/strong>Slo\u017een\u00ed l\u00e9\u010div\u00e9ho p\u0159\u00edpravku je inspirov\u00e1no velice \u00fa\u010dinn\u00fdm l\u00e9kem IMMODIN, nicm\u00e9n\u011b nov\u011b inovov\u00e1no ve form\u011b sv\u011btov\u011b unik\u00e1tn\u00ed lyofilizovan\u00e9 tablety. Konkr\u00e9tn\u011b se jedn\u00e1 o dialyz\u00e1t homogenitu hum\u00e1nn\u00edch leukocyt\u016f, fyziologicky vyv\u00e1\u017een\u00e1 sm\u011bs biologicky aktivn\u00edch l\u00e1tek, kter\u00e9 se v organizmu p\u0159irozen\u011b vyskytuj\u00ed a vykon\u00e1vaj\u00ed specifick\u00e9 funkce v imunitn\u00edm syst\u00e9mu. Lidsk\u00e9 leukocyty jsou p\u0159irozen\u00fdm n\u00e1strojem imunitn\u00ed soustavy. Hlavn\u00edm posl\u00e1n\u00edm tohoto l\u00e9ku je normalizace reakc\u00ed bun\u011b\u010dn\u00e9 imunity pomoc\u00ed p\u0159enosu specifick\u00e9 bun\u011b\u010dn\u00e9 imunity z d\u00e1rce na p\u0159\u00edjemce (transfer faktor). Sv\u00fdm p\u0159\u00edm\u00fdm p\u016fsoben\u00edm na imunokompetentn\u00ed bu\u0148ky zasahuje do poru\u0161en\u00e9 bun\u011b\u010dn\u00e9 imunity, upravuje a normalizuje ji.<\/p>\n\n\n\n

Nov\u00fd p\u0159\u00edpravek m\u00e1 krom\u011b komfortn\u011bj\u0161\u00ed formy pod\u00e1n\u00ed tak\u00e9 efektivn\u011bj\u0161\u00ed metodu v\u00fdroby, akcentuj\u00edc\u00ed trendy v aktu\u00e1ln\u00edch purifika\u010dn\u00edch technologi\u00edch. Technologie p\u0159\u00edpravy c\u00edl\u00ed na maxim\u00e1ln\u00ed bezpe\u010dnost p\u0159\u00edpravku. Obsah API v jedn\u00e9 tablet\u011b je 10 mg a je identick\u00fd s d\u00e1vkov\u00e1n\u00edm alternativn\u00edho p\u0159\u00edpravku Immodinu (1 d\u00e1vka = jedna lyofilizovan\u00e1 tableta, obsahuj\u00edc\u00ed  dialyz\u00e1t z 200 mil. lidsk\u00fdch leukocyt\u016f). P\u0159\u00edpravek TFI m\u00e1 zavedeny standardizovan\u00e9 metody technologie p\u0159\u00edpravy a jejich fyzik\u00e1ln\u011b-chemick\u00e9 kontroly,  v souladu s po\u017eadavky GMP, kladen\u00fdmi na tento typ \u010dinnost\u00ed. TFI byl v dal\u0161\u00edch etap\u00e1ch testov\u00e1n in vitro a in vivo na bezpe\u010dnost a na biologickou aktivitu.<\/p>\n\n\n\n

CO JSOU TO TRANSFER FAKTORY?<\/strong><\/h2>\n\n\n\n

Transfer faktory byly objeveny a pops\u00e1ny Dr. H Sherwood Lawrencem koncem \u010dty\u0159ic\u00e1t\u00fdch let minul\u00e9ho stolet\u00ed. Dodnes jde o dosud nep\u0159esn\u011b definovanou sm\u011bs <\/strong>leukocyt\u00e1rn\u00edch<\/strong> bun\u011b\u010dn\u00fdch fragment\u016f, nukleov\u00fdch kyselin<\/strong> a <\/strong>aminokyselin<\/strong>, kter\u00e9 posiluj\u00ed efektivitu imunitn\u00edho syst\u00e9mu v jeho boji proti r\u016fzn\u00fdm onemocn\u011bn\u00edm.<\/p>\n\n\n\n

Podstata \u00fa\u010dinnosti transfer faktor\u016f spo\u010d\u00edv\u00e1 v p\u0159enosu sign\u00e1ln\u00edch informac\u00ed a modulaci \u010dinnosti imunitn\u00edho syst\u00e9mu. Transfer faktory jsou \u00fasp\u011b\u0161n\u011b pou\u017e\u00edv\u00e1ny v l\u00e9\u010db\u011b virov\u00fdch, mykotick\u00fdch, bakteri\u00e1ln\u00edch nebo parazit\u00e1rn\u00edch infekc\u00ed. Jsou publikov\u00e1ny kazuistiky v onkologick\u00e9 l\u00e9\u010db\u011b, p\u0159i zvl\u00e1d\u00e1n\u00ed r\u016fzn\u00fdch imunodeficienc\u00ed, autoimunn\u00edch onemocn\u011bn\u00ed a r\u016fzn\u00fdch alergi\u00ed atd.<\/p>\n\n\n\n

HISTORIE A SOU\u010cASN\u00c1 SITUACE<\/strong><\/h2>\n\n\n\n

V \u010cesk\u00e9 republice resp. v d\u0159\u00edv\u011bj\u0161\u00edm \u010ceskoslovensku m\u00e1 studium a terapeutick\u00e9 vyu\u017e\u00edv\u00e1n\u00ed r\u016fzn\u00fdch transfer faktor\u016f (TF) dlouhou tradici s ko\u0159eny sahaj\u00edc\u00edmi a\u017e do 60 let minul\u00e9ho stolet\u00ed, kdy doktor Pek\u00e1rek prov\u00e1d\u011bl prvn\u00ed experimenty.<\/p>\n\n\n\n

V sou\u010dasn\u00e9 dob\u011b vyr\u00e1b\u011bn\u00e9 transfer faktory (TF) obecn\u011b vyu\u017e\u00edvaj\u00ed r\u016fzn\u00e9 surovinov\u00e9 zdroje (hum\u00e1nn\u00ed leukocyty, zv\u00ed\u0159ec\u00ed b\u00edl\u00e9 krvinky). V\u00fdroba zalo\u017een\u00e1 na zv\u00ed\u0159ec\u00edch b\u00edl\u00fdch krvink\u00e1ch (komer\u010dn\u00ed p\u0159\u00edpravek IMUNOR) bohu\u017eel nereflektuje reakce lidsk\u00fdch imunitn\u00edch mechanism\u016f na lidsk\u00e9 patogeny. Nejstar\u0161\u00ed vyr\u00e1b\u011bn\u00fd TF v \u010cesk\u00e9 republice z hum\u00e1nn\u00edch leukocyt\u016f je p\u0159\u00edpravek s komer\u010dn\u00edm n\u00e1zvem IMMODIN. Jde o l\u00e9\u010div\u00fd p\u0159\u00edpravek, kter\u00fd je pod\u00e1v\u00e1n injek\u010dn\u00ed formou. Proto\u017ee je injek\u010dn\u011b aplikov\u00e1n velk\u00fd objem, je tato forma podko\u017en\u00edho pod\u00e1n\u00ed velmi bolestiv\u00e1. Na druhou stranu je ov\u011b\u0159eno, \u017ee pro vyvol\u00e1n\u00ed terapeutick\u00e9ho efektu nen\u00ed injek\u010dn\u00ed pod\u00e1n\u00ed TF bezpodm\u00edne\u010dn\u011b nutnou podm\u00ednkou. Jako aplika\u010dn\u011b v\u00fdhodn\u00e9 se jev\u00ed r\u016fzn\u00e9 formy nebolestiv\u00e9 peror\u00e1ln\u00ed aplikace (IMUNOR). TFI je proto jedine\u010dn\u00fd imunomodula\u010dn\u00ed l\u00e9k vyr\u00e1b\u011bn\u00fd z lidsk\u00fdch leukocyt\u016f peror\u00e1ln\u011b pod\u00e1van\u00fd ve form\u011b lyofilizovan\u00e9 tablety!<\/strong><\/p>\n\n\n\n

INDIKACE<\/h2>\n\n\n\n

TFI bude indikov\u00e1n k l\u00e9\u010db\u011b p\u0159edev\u0161\u00edm v p\u0159\u00edpadech laboratorn\u011b prok\u00e1zan\u00e9 poruchy bun\u011b\u010dn\u00e9 imunity, d\u00e1le v klinick\u00fdch p\u0159\u00edpadech onemocn\u011bn\u00ed, o nich\u017e je zn\u00e1mo, \u017ee jsou obvykle s poruchou bun\u011b\u010dn\u00e9 imunity spojeny. D\u00e1le bude indikov\u00e1n p\u0159i deficienc\u00edch humor\u00e1ln\u00ed imunity s laboratorn\u011b prok\u00e1zan\u00fdmi sn\u00ed\u017een\u00fdmi hladinami imunoglobul\u00edn\u016f a kol\u00edsav\u00fdmi n\u00e1lezu poru\u0161en\u00e9 bun\u011b\u010dn\u00e9 imunity, s klinick\u00fdm obrazem recidivuj\u00edc\u00edch infekt\u016f r\u016fzn\u00fdch lokalit.<\/p>\n\n\n\n

SV\u011aTOV\u011a UNIK\u00c1TN\u00cd L\u00c9K VE FORM\u011a LYOFILIZOVAN\u00c9 TABLETY<\/strong><\/h2>\n\n\n\n

Nov\u00fd l\u00e9k je v\u00fdsledkem grantu v r\u00e1mci opera\u010dn\u00edho programu Podnik\u00e1n\u00ed a inovace pro konkurenceschopnost 2014 \u2013 2020. <\/strong>Slo\u017een\u00ed l\u00e9\u010div\u00e9ho p\u0159\u00edpravku je inspirov\u00e1no velice \u00fa\u010dinn\u00fdm l\u00e9kem IMMODIN. Je pou\u017eit obdobn\u00fd dialyz\u00e1t homogenitu hum\u00e1nn\u00edch leukocyt\u016f, nicm\u00e9n\u011b ve form\u011b lyofilizovan\u00e9 tablety. Lyofilizovan\u00e1 tableta, jako nov\u00e1 l\u00e9kov\u00e1 forma l\u00e9\u010div\u00fdch p\u0159\u00edpravk\u016f na b\u00e1zi transfer faktor\u016f, nen\u00ed dosud vyr\u00e1b\u011bna a registrov\u00e1na ani v \u010cesk\u00e9 republice ani nikde ve sv\u011bt\u011b.<\/strong> K disoluci lyofilizovan\u00e9 tablety dojde je\u0161t\u011b v \u00fastech, d\u0159\u00edve ne\u017e ji pacient sta\u010d\u00ed polknout a l\u00e9\u010div\u00e1 l\u00e1tka tak z\u016fstane del\u0161\u00ed dobu v kontaktu s imunologicky aktivn\u00ed buk\u00e1ln\u00ed sliznic\u00ed a nen\u00ed degradov\u00e1na v dal\u0161\u00edch \u010d\u00e1stech tr\u00e1vic\u00edho traktu.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TFI je nov\u00e1 l\u00e9kov\u00e1 forma specifick\u00fdch imunomodul\u00e1tor\u016f na b\u00e1zi transfer faktor\u016f (TF) pod\u00e1van\u00e1 peror\u00e1ln\u011b ve form\u011b lyofilizovan\u00e9 tablety. Slo\u017een\u00ed l\u00e9\u010div\u00e9ho p\u0159\u00edpravku je inspirov\u00e1no velice \u00fa\u010dinn\u00fdm l\u00e9kem IMMODIN, nicm\u00e9n\u011b nov\u011b inovov\u00e1no ve form\u011b sv\u011btov\u011b unik\u00e1tn\u00ed lyofilizovan\u00e9 tablety. Konkr\u00e9tn\u011b se jedn\u00e1 o dialyz\u00e1t homogenitu hum\u00e1nn\u00edch leukocyt\u016f, fyziologicky vyv\u00e1\u017een\u00e1 sm\u011bs biologicky aktivn\u00edch l\u00e1tek, kter\u00e9 se v organizmu p\u0159irozen\u011b… \u010c\u00edst d\u00e1le »Transfer faktor TFI<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":118,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"class_list":["post-108","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/pages\/108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=108"}],"version-history":[{"count":5,"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/pages\/108\/revisions"}],"predecessor-version":[{"id":162,"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/pages\/108\/revisions\/162"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=\/wp\/v2\/media\/118"}],"wp:attachment":[{"href":"https:\/\/www.aumedimmunology.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}